Grignard Reagents Acros Organics 20967, 33165, 31737, etc.

Magnesium halides with the general structure R-Mg-X, where R = alkyl, alkenyl or aryl and X = halogen, are called Grignard reagents in honor of their inventor.

They are extremely valuable and widely used synthetic tools, mainly as carbanions in nucleophilic additives and substitution reactions, as well as in a number of other transformations.

Grignard reagents are usually obtained by the reaction of organic halide with metallic magnesium (metallization) in dry diethyl ether or tetrahydrofuran.

In addition to metallization, many other methods of preparation of Grignard reagents have been developed:

• transmetallization of other organometallic compounds with anhydrous magnesium salts,
• sulfoxide / magnesium exchange,
• carbenoid homologation,
• reaction with highly active magnesium,
• reaction with anthracene magnesium complex,
• iodine-magnesium exchange,
• exchange reaction using organo-magnesium complexes "ata",
• Grignard formation catalyzed by transition metals,
• mercury-magnesium exchange.

Articles: 20967, 33165, 31737, 33166, 37725, 25257, 37744 and others .